硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物
收稿日期: 2012-10-14
修回日期: 2012-11-25
网络出版日期: 2012-11-26
基金资助
内蒙古教育厅基金(No. NJZY12199)、内蒙古包头师范学院青年基金(No. BSYJ2011-16)资助项目.
One Pot Synthesis of Multiaryl-Substituted β-Amino Ketone Compo- unds Catalyzed by Silica-Supported Rare Earth Terbium Chloride
Received date: 2012-10-14
Revised date: 2012-11-25
Online published: 2012-11-26
Supported by
Project supported by the Inner Mongolia Ministry of Education of China (No. NJZY12199), the Youth Foundation of Normal College of Baotou (No. BSYJ2011-16).
以苯乙酮、芳香醛和芳香胺为原料, 以硅胶负载稀土氯化铽作为环境友好型催化剂, 在室温条件下, 一步合成31个多取代的β-氨基酮类化合物. 其中部分为新的化合物. 所有化合物结构经过1H NMR, IR和元素分析确定. 研究结果表明, 硅胶负载稀土氯化铽作为一种新型环境友好催化剂, 催化剂自身具有负载量稳定, 活化条件简单, 催化产率高. 催化反应体系条件温和, 操作简单, 不污染环境和催化剂重复回收利用等优点.
马学林 , 张骁勇 , 李璇 , 刘永明 . 硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物[J]. 有机化学, 2013 , 33(03) : 602 -606 . DOI: 10.6023/cjoc201210021
A series of multiaryl-substituted β-amino ketone compounds were synthesized by one pot reaction using acetophenone, aromatic aldehydes and aromatic amines as starting materials and silica-supported rare earth terbium chloride as catalyst. The products were characterized by 1H NMR, IR and elemental analysis. The results showed that the support rate of catalyst was very stable and the activation condition of the catalyst was simple. This protocol has advantages of mild condition, high yield, simple work-up, environmental friendly procedure and the catalyst being able to reuse.
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