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2013 , Vol. 33 >Issue 03: 643 - 647

DOI: https://doi.org/10.6023/cjoc201209043

研究简报

新型苯并咪唑环蕃的合成与晶体结构研究

  • 侯晓萌 ,
  • 徐林飞 ,
  • 唐雪松 ,
  • 宋阳 ,
  • 白银娟
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  • 合成与天然功能分子化学教育部重点实验室 西北大学化学与材料科学学院 西安 710069

收稿日期: 2012-09-28

  修回日期: 2012-11-29

  网络出版日期: 2012-12-10

基金资助

国家自然科学基金(No. 21042002)和陕西省自然科学基金(No. 2010JM2001)资助项目.

收起

Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes

  • Hou Xiaomeng ,
  • Xu Linfei ,
  • Tang Xuesong ,
  • Song Yang ,
  • Bai Yinjuan
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  • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069

Received date: 2012-09-28

  Revised date: 2012-11-29

  Online published: 2012-12-10

Supported by

Project supported by the National Natural Science Foundation of China (No. 21042002) and the Natural Science Foundation of Shaanxi Province (No. 2010JM2001).

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摘要

以二溴甲基苯(o, m, p)为原料, 分别与2-巯基苯并咪唑环化合成相应的含硫苯并咪唑环蕃, 实验发现二溴甲基取代位置对反应结果有很大影响, o-位取代很易生成[1:1]型环化产物, p-位取代则主要得到链状产物, m-位取代环化产物较复杂, 但以[2:2]型环化产物为主. 产物结构通过1H NMR, IR, HRMS进行了表征, 并得到了1-3a的X射线单晶衍射晶体结构, 对其晶体结构进行了分析.

本文引用格式

侯晓萌 , 徐林飞 , 唐雪松 , 宋阳 , 白银娟 . 新型苯并咪唑环蕃的合成与晶体结构研究[J]. 有机化学, 2013 , 33(03) : 643 -647 . DOI: 10.6023/cjoc201209043

Abstract

The novel sulfur-containing benzimidazole cyclophanes were synthesized from bis(bromomethyl)benzene (o, m, p) and 2-benzimidazolinthion, respectively. The reaction showed that bromomethyl positions effected the aim compounds very much. It was easy for o-substituted to generate the [1:1] type cyclization product. p-Substituted obtained chain product, and m-substituted benzene pruduced the [2:2] type cyclization compound as main product. The lead compounds were characterized by 1H NMR, IR, HRMS, and the structure of 1-3a was determined by X-ray diffraction method.

Key words： benzimidazole cyclophane; synthesis; characterization; crystal structure

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