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2013 , Vol. 33 >Issue 05: 1108 - 1112

DOI: https://doi.org/10.6023/cjoc201210019

研究简报

微波辐射下N-[4-(香豆素-3-基)噻唑-2-基]芳醛腙类化合物的合成及生物活性研究

  • 袁明月 ,
  • 刘伟华 ,
  • 张英群 ,
  • 闫红飞 ,
  • 张冬暖 ,
  • 刘卉闵 ,
  • 王建平
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  • a 河北农业大学理学院 保定 071001;
    b 河北农业大学植物保护学院 保定 071001;
    c 河北农业大学动物科技学院 保定 071001

收稿日期: 2012-10-17

  修回日期: 2012-12-21

  网络出版日期: 2013-01-07

基金资助

河北省教育厅计划项目(No. 2009435)、河北农业大学非生命学科和新兴学科科研发展基金(No. 2009020)资助项目.

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Synthesis and Biological Activity of N-[4-(Coumarin-3-yl)thiazol-2-yl] Aromatic Aldehyde Hydrazones under Microwave Irradiation

  • Yuan Mingyue ,
  • Liu Weihua ,
  • Zhang Yingqun ,
  • Yan Hongfei ,
  • Zhang Dongnuan ,
  • Liu Huimin ,
  • Wang Jianping
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  • a College of Science, Agricultural University of Hebei, Baoding 071001;
    b College of Plant Protection, Agricultural University of Hebei, Baoding 071001;
    c College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001

Received date: 2012-10-17

  Revised date: 2012-12-21

  Online published: 2013-01-07

Supported by

Project supported by the Foundation of Hebei Educational Committee (No. 2009435), the Non-life disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No. 2009020).

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摘要

由含不同取代基的芳香醛与氨基硫脲缩合成缩氨基硫脲, 继而与α-溴代乙酰基香豆素经微波辐射合成了14种新的N-[4-(香豆素-3-基)噻唑-2-基]芳醛腙类化合物, 产率达到69%～97%. 其结构通过1H NMR, IR和HRMS进行了确证. 试验表明部分目标化合物具有一定的抑菌生物活性.

关键词： N-[4-(香豆素-3-基)噻唑-2-基]芳醛腙; 合成; 微波; 抑菌活性

本文引用格式

袁明月 , 刘伟华 , 张英群 , 闫红飞 , 张冬暖 , 刘卉闵 , 王建平 . 微波辐射下N-[4-(香豆素-3-基)噻唑-2-基]芳醛腙类化合物的合成及生物活性研究[J]. 有机化学, 2013 , 33(05) : 1108 -1112 . DOI: 10.6023/cjoc201210019

Abstract

A series of N-[4-(coumarin-3-yl)thiazol-2-yl] aromatic aldehyde hydrazones have been prepared via the condensation of thiosemicarbazone with α-bromoacetyl coumarin, using microwave heating methodology. The yield was ranged from 69% to 97%. Their chemical structures have been confirmed by means of IR, 1H NMR and HRMS. Bioassay of the title compounds indicated that some of them exhibited good antibacterial activity.

Key words： N-[(4-(coumarin-3-yl)thiazol-2-yl) aromatic aldehyde hydrazones; synthesis; microwave; antibacterial activity

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