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2013 , Vol. 33 >Issue 06: 1349 - 1351

DOI: https://doi.org/10.6023/cjoc201301083

研究简报

黄山药根茎中一个新睡茄内酯苷

  • 单晓庆 ,
  • 梁健 ,
  • 丁立生 ,
  • 王晓玲 ,
  • 彭树林
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  • a 中国科学院成都生物研究所山地生态恢复与生物资源利用重点实验室 成都 610041;
    b 西南民族大学少数民族药物研究所 成都 610041

收稿日期: 2013-02-01

  修回日期: 2013-03-06

  网络出版日期: 2013-03-28

基金资助

国家自然科学基金(Nos.30973634, 21072185)资助项目.

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A Novel Withanolide Glucoside from the Rhizomes of Dioscorea panthaica

  • Shan Xiaoqing ,
  • Liang Jian ,
  • Ding Lisheng ,
  • Wang Xiaoling ,
  • Peng Shulin
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  • a Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041;
    b Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041

Received date: 2013-02-01

  Revised date: 2013-03-06

  Online published: 2013-03-28

Supported by

Project supported by the National Natural Science Foundation of China (Nos.30973634, 21072185).

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摘要

从地奥心血康原料药材黄山药根茎中分离得到一个结构新颖的微量成分.其结构通过包括2-D NMR在内的波谱分析确定为葡萄糖基接在内酯环上的多氧化withanolide型麦角甾内酯皂苷, 命名为薯蓣内酯葡糖苷.

关键词： 黄山药; 睡茄内酯苷; 薯蓣内酯葡糖苷

本文引用格式

单晓庆 , 梁健 , 丁立生 , 王晓玲 , 彭树林 . 黄山药根茎中一个新睡茄内酯苷[J]. 有机化学, 2013 , 33(06) : 1349 -1351 . DOI: 10.6023/cjoc201301083

Abstract

A novel withanolide type C28-steroid saponin, named dioscolide glucoside, was isolated from the rhizomes of Dioscorea panthaica Prain et Buckill.The structure was elucidated as (20S,22R,24R,25S)-1-oxo-2α,3α;6α,7α-diepoxy-5α,16α,25α-trihydroxy-withanolide-27-O-glucopyranoside by spectroscopic evidence including 2D-NMR.

Key words： Dioscorea panthaica; withanolide glucoside; dioscolide glucoside

参考文献

[1] Li, B.-G.Research and Industrial Development of Chinese Medicinal Plant Resources of Dioscorea, Science Press, Beijing, 2006, pp.5～32 (In Chinese).(李伯刚, 中国药用薯蓣资源植物研究与产业化开发, 科学出版社, 北京, 2006, pp.5～32.)
[2] Chinese Pharmacopoeia Commission Chinese Pharmacopoeia 2010, Vol.1, China Medical Science Press, Beijing, 2010, pp.671～672 (in Chinese).(国家药典委员会, 中华人民共和国药典(2010年版, 一部), 中国医药科技出版社, 北京, 2010, pp.671～672.)
[3] Tang, S.-R.; Yang, R.-T.; Pan, F.-S.; Zhao, A.-M.; Pang, Z.-J.Plant Resour.Environ.2007, 16(2), 64 (in Chinese).(唐世蓉, 杨如同, 潘福生, 赵爱明, 庞自洁, 植物资源与环境学报, 2007, 16(2), 64.)
[4] Misra, L.; Lal, P.; Sangwan, R.S.; Sangwan, N.S.; Uniyal, G.C.; Tuli, R.Phytochemistry 2005, 66, 2702.
[5] Su, B.N.; Misico, R.; Park, E.J.; Santarsiero, B.D.; Mesecar, A.D.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D.Tetrahedron 2002, 58, 3453.
[6] Liu, H.-Y.; Ni, W.; Xie, B.-B.; Zhou, L.-Y.; Hao, X.-J.; Wang, X.; Chen, C.-X.Chem.Pharm.Bull.2006, 54, 992.
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