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2013 , Vol. 33 >Issue 06: 1345 - 1348

DOI: https://doi.org/10.6023/cjoc201303019

研究简报

野花椒中2个新苯丙素成分的研究

  • 朱德荣 ,
  • 祝丹 ,
  • 陈玉 ,
  • 梅之南 ,
  • 杨光忠
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  • a 广东医学院药物化学与药分教研室 东莞 523808;
    b 中南民族大学药学院 武汉 430074;
    c 中南民族大学化学与材料科学学院 武汉 430074

收稿日期: 2013-03-13

  修回日期: 2013-04-04

  网络出版日期: 2013-04-17

基金资助

国家科技支撑计划(No.2012BAI27B06)资助项目.

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Two New Phenylpropanoids form Zanthoxylum utile Huang

  • Zhu Derong ,
  • Zhu Dan ,
  • Chen Yu ,
  • Mei Zhinan ,
  • Yang Guangzhong
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  • a Department of Medicinal Chemistry and Pharm-analysis, Guangdong Medical University, Dongguan 523808;
    b College of Pharmacy, South-Central University for Nationalities, Wuhan 430074;
    c College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074

Received date: 2013-03-13

  Revised date: 2013-04-04

  Online published: 2013-04-17

Supported by

Project supported by the National Key Technology R&D Program in the 12th Five Year Plan of China (No.2012BAI27B06).

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摘要

运用正相、反相硅胶柱层析和HPLC对野花椒(Zanthoxylum utile Huang)的化学成分进行研究, 并利用现代波谱技术鉴定化合物的结构.从野花椒茎木乙醇提取物中分离得到14个化合物, 分别鉴定为robustine (1), 香兰子酸(2), dihydroalatamide (3), tembamide (4), N-benzoyltyramine (5), blumenol (6), blumenol C (7), 芥子醛 (8), (E)-3-(3,4,5-三甲氧基苯基)-2-丙烯醇(9), 松柏醇 (10), integrifoliodiol (11), 两面针氧新木脂素(12), 以及两个新的苯丙素类成分, 分别命名为野花椒甲素(13)和乙素(14).所有化合物为首次从该植物中分离得到.

关键词： 花椒属; 野花椒; 苯丙素; 分离; 结构鉴定

本文引用格式

朱德荣 , 祝丹 , 陈玉 , 梅之南 , 杨光忠 . 野花椒中2个新苯丙素成分的研究[J]. 有机化学, 2013 , 33(06) : 1345 -1348 . DOI: 10.6023/cjoc201303019

Abstract

To study the chemical constituents of Zanthoxylum utile Huang, the chemical constituents were isolated and purified by normal, reverse column chromatography and HPLC.Their structures were identified by spectral analysis.14 compounds were isolated from the EtOH extract of Zanthoxylum utile Huang.They were identified as robustine (1), vanillic acid (2), dihydroalatamide (3), tembamide (4), N-benzoyltyramine (5), blumenol (6), blumenol C (7), sinapaldehyde (8), (E)-3-(3,4,5-trimethoxy-phenyl)-prop-2-en-1-ol (9), coniferyl alcohol (10), integrifoliodiol (11), nitidanin (12), and two new phenylpropanoids named as utilines A (13) and B (14).All compounds were isolated from the plant for the first time.

Key words： Zanthoxylum L.; Zanthoxylum utile Huang; phenylpropanoids; isolation; structure identification

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