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2013 , Vol. 33 >Issue 06: 1135 - 1143

DOI: https://doi.org/10.6023/cjoc201304001

研究专题

一些特异生境微生物的化学成分及其抗肿瘤活性研究

  • 李瑶瑶 ,
  • 沈月毛
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  • 山东大学药学院 济南 250012

收稿日期: 2013-04-01

  修回日期: 2013-05-06

  网络出版日期: 2013-05-08

基金资助

国家自然科学基金(Nos.81273384, 31028019, 90913024, 30500632, 30430020, 30325044, 30070007)资助项目.

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Chemical Components of Some Microorganisms Isolated from Specific Habitats and Their Antitumor Activities

  • Li Yaoyao ,
  • Shen Yuemao
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  • Schoole of Pharmaceutical Sciences, Shandong Univercity, Jinan 250012

Received date: 2013-04-01

  Revised date: 2013-05-06

  Online published: 2013-05-08

Supported by

Project supported by the National Natural Science Foundation of China (Nos.81273384, 31028019, 90913024, 30500632, 30430020, 30325044, 30070007).

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摘要

癌症发病率和耐药性的不断攀升, 促使新结构和新作用机制药物的发现更为迫切.近年来, 特异生境微生物的化学成分和生物活性研究日益受到关注.本课题组通过对药用植物内生菌和海洋微生物的分离、筛选和系统的化学成分分离, 获得了一些结构新颖复杂的活性天然产物, 并对其中2个化合物的抗肿瘤作用机制进行了研究.这些结果表明特异生境微生物蕴含着丰富的新活性化学成分, 值得深入发掘.

关键词： 植物内生菌; 海洋微生物; 天然产物; 抗肿瘤作用

本文引用格式

李瑶瑶 , 沈月毛 . 一些特异生境微生物的化学成分及其抗肿瘤活性研究[J]. 有机化学, 2013 , 33(06) : 1135 -1143 . DOI: 10.6023/cjoc201304001

Abstract

The discovery of new anti-tumor drugs is a pressing and continual need for human health due to the constant emergence of drug resistant tumor cell lines, and the rising occurrence of cancer.In recent years, researchers are paying more and more attention to the chemical components of microorganisms isolated from specific habitats and their bioactivities.Our group isolated a large number of new bioactive natural products, most with complex structures, from endophytes of medicinal plants and marine microbes.Moreover, the antitumor mechnisms and targets of two classes of compounds were investigated.Our results indicated that these special microbes are of great potential for new bioactive compounds and deserve further explorations.

Key words： endophytes of medicinal plant; marine microbes; natural product; anti-tumor action

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