达菲合成最新进展
收稿日期: 2013-03-27
修回日期: 2013-05-09
网络出版日期: 2013-05-13
基金资助
国家自然科学基金委(Nos.20972059, 21290180);教育部长江学者创新团队(No.IRT1138)和中央高校基本科研费(No.lzujbky-2013-ct02)资助项目.
Recent Progress in the Synthesis of Tamiflu
Received date: 2013-03-27
Revised date: 2013-05-09
Online published: 2013-05-13
Supported by
Project supported by the National Natural Science Foundation of China (Nos.20972059, 21290180), the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1138) and the Fundamental Research Funds for the Central Universities (No.lzujbky-2013-ct02).
张田财 , 鲁慧 , 张辅民 , 程军 , 刘天阳 . 达菲合成最新进展[J]. 有机化学, 2013 , 33(06) : 1235 -1243 . DOI: 10.6023/cjoc201303044
Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world.Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date.In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized.
Key words: tamiflu; drug; total synthesis
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