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2013 , Vol. 33 >Issue 9: 1988 - 1993

DOI: https://doi.org/10.6023/cjoc201304028

研究简报

N-亚苄基橙皮素腙及类似物的合成与细胞活性

  • 刘志平 ,
  • 韦万兴 ,
  • 甘春芳 ,
  • 黄燕敏 ,
  • 刘盛 ,
  • 周敏 ,
  • 崔建国
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  • a 广西大学化学化工学院 南宁 530004;
    b 广西师范学院化学与生命科学学院 南宁 530001

收稿日期: 2013-04-18

  修回日期: 2013-05-22

  网络出版日期: 2013-05-31

基金资助

国家自然科学基金(No. 81060261);广西科学自然科学基金重点(No. 2011jjD20002)资助项目

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Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

  • Liu Zhiping ,
  • Wei Wanxing ,
  • Gan Chunfang ,
  • Huang Yanmin ,
  • Liu Sheng ,
  • Zhou Min ,
  • Cui Jianguo
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  • a College of Chemistry and Chemical Engineer, Guangxi University, Nanning 530004;
    b College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001

Received date: 2013-04-18

  Revised date: 2013-05-22

  Online published: 2013-05-31

Supported by

Project supported by the National Natural Science Foundation of China (No. 81060261) and the Natural Science Foundation of Guangxi Province (No. 2011jjD20002)

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摘要

以天然橙皮素(1)为原料, 与水合肼反应得到了橙皮素腙(2). 2分别与各种取代的芳香醛反应首次合成了8个N-亚苄基橙皮素腙3～10及6个类似物11～16. 所合成产物通过NMR, IR, HR-ESI-MS方法进行了结构确证. MTT(噻唑蓝)蛋白染色法体外抑制肿瘤增值活性测试发现化合物5, 7, 10, 16对胃癌细胞SGC-7901有显著的抑制活性.

关键词： 橙皮素; 橙皮素腙; N-亚苄基; 细胞活性

本文引用格式

刘志平 , 韦万兴 , 甘春芳 , 黄燕敏 , 刘盛 , 周敏 , 崔建国 . N-亚苄基橙皮素腙及类似物的合成与细胞活性[J]. 有机化学, 2013 , 33(9) : 1988 -1993 . DOI: 10.6023/cjoc201304028

Abstract

Hesperitin hydrazone (2) was generated by the reaction of natural hesperitin (1) as raw material with hydrazine hydrate. Eight N-benzylidene hesperitin hydrazones 3～10 and six analogues 11～16 were synthesized by the reaction of 2 with various aldehydes, respectively. The structures of all reaction products were confirmed by NMR, IR and HR-MS techniques. And the cytotoxity against human cancer cell SGC-7901 of the synthesized compounds was also evaluated. The results showed 5, 7, 10 and 16 exhibiting distinct cytotoxity against SGC-7901.

Key words： hesperitin; hesperitin hydrazones; N-benzylidene; cytotoxicity

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