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2013 , Vol. 33 >Issue 06: 1333 - 1336

DOI: https://doi.org/10.6023/cjoc201305025

研究简报

海南暗罗根中一个新的克罗烷型二萜

  • 李小宝 ,
  • 宋小平 ,
  • 陈光英 ,
  • 韩长日 ,
  • 陈文豪 ,
  • 郑彩娟 ,
  • 宋鑫明
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  • 海南师范大学化学与化工学院 热带药用植物化学教育部重点实验室 海口 571158

收稿日期: 2013-05-15

  修回日期: 2013-05-28

  网络出版日期: 2013-06-04

基金资助

国家自然科学基金(Nos.81160391, 21166009, 21162009)和科技部973计划前期研究专项(No.2011CB512010)资助项目.

收起

A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

  • Li Xiaobao ,
  • Song Xiaoping ,
  • Chen Guangying ,
  • Han Changri ,
  • Chen Wenhao ,
  • Zheng Caijuan ,
  • Song Xinming
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  • Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received date: 2013-05-15

  Revised date: 2013-05-28

  Online published: 2013-06-04

Supported by

Project supported by the National Natural Science Foundation of China (Nos.81160391, 21166009 and 21162009), the 973 Research Program of the Ministry of Science and Technology of China (No.2011CB512010).

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摘要

采用硅胶柱层析, 制备薄层层析等色谱方法, 从海南暗罗根中分离得到8 个二萜类化合物, 分别鉴定为polyalimide A (1), kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4),3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), solidagonal acid methyl ester (8).其中化合物1为新化合物, 化合物5首次从番荔枝科分离得到, 所有化合物首次从该植物中分离得到.化合物2和3对人肿瘤细胞SPCA-1, SGC-7901 和K-562显示微弱的细胞毒性.

关键词： 暗罗属; 海南暗罗; polyalmide A

本文引用格式

李小宝 , 宋小平 , 陈光英 , 韩长日 , 陈文豪 , 郑彩娟 , 宋鑫明 . 海南暗罗根中一个新的克罗烷型二萜[J]. 有机化学, 2013 , 33(06) : 1333 -1336 . DOI: 10.6023/cjoc201305025

Abstract

Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy (TLC).Their structures were elucidated as polyalimide A (1),kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4), 3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), and solidagonal acid methyl ester (8).Compound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were isolated for the first time from this plant material.Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

Key words： Polyalthia; Polyalthia laui Merr.; polyalimide A

参考文献

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