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2013 , Vol. 33 >Issue 10: 2205 - 2209

DOI: https://doi.org/10.6023/cjoc201304025

研究论文

Cs2CO3催化三组分“一锅法”合成5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物

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  • 新疆大学化学化工学院 石油天然气精细化工教育部&新疆维吾尔自治区重点实验室 乌鲁木齐 830046

收稿日期: 2013-04-17

  修回日期: 2013-06-06

  网络出版日期: 2013-06-09

基金资助

新疆维吾尔自治区自然科学基金(No. 2009211A02)资助项目

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Cs2CO3-Promoted One-Pot Three-Component Synthesis of 5-Amino-7-aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile Derivatives

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  • Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Received date: 2013-04-17

  Revised date: 2013-06-06

  Online published: 2013-06-09

Supported by

Project supported by the Natural Science Foundation of Xinjiang Uyghur Autonomous Region (No. 2009211A02).

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摘要

在Cs2CO3催化下, 以3-氨基-1,2,4-三唑、芳香醛、丙二腈为原料, 经三组分一锅法合成了一系列5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物. 利用1H NMR, IR, MS对产物进行了结构表征. 该方法具有操作简单方便、产率优良等优点.

关键词： 三组分反应; 一锅法合成; 1,2,4-三唑[4,3-a]嘧啶; Cs2CO3催化

本文引用格式

王立举, 阿布拉江·克依木, 古丽斯坦·阿布里来提, 卡马勒别克·吾买尔, 糟新民 . Cs2CO3催化三组分“一锅法”合成5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物[J]. 有机化学, 2013 , 33(10) : 2205 -2209 . DOI: 10.6023/cjoc201304025

Abstract

A series of 5-amino-7-aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile derivatives were synthesized by three-component one-pot reaction of 3-amino-1,2,4-triazole, aryl aldehyde and malononitrile in the presence of Cs2CO3 as a catalyst. All target compounds were characterized by 1H NMR, IR and MS techniques. The advantages of this method are simple, convenient and improved yields.

Key words： three-component reaction; one-pot synthesis; 1,2,4-triazolo[4,3-a]pyrimidine; Cs2CO3-promoted

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