综述与进展

肉芝软珊瑚属中二聚西松烷型二萜化合物的化学和生物活性研究进展

  • 李玉芬 ,
  • 梁林富 ,
  • 萧伟 ,
  • 梁敬钰 ,
  • 郭跃伟
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  • a 中国科学院上海药物研究所国家新药研究重点实验室 上海 201203;
    b 中国药科大学天然药物化学教研室 南京 210009;
    c 江苏康缘药业股份有限公司 连云港 222001

收稿日期: 2013-04-25

  修回日期: 2013-06-09

  网络出版日期: 2013-06-09

基金资助

国家海洋“863”计划(Nos.2011AA09070102, 2013AA092902);国家自然科学基金(Nos.81273430, 21072204, 21021063);中国科学院国家新药研究重点实验室项目(No.SIMM1203ZZ-03, SIMM1105KF-04);欧盟第七框架IRSES (2010~2014)资助项目.

Progress in the Study of Biscembranoides from the Soft Corals of the Genus Sarcophyton

  • Li Yufen ,
  • Liang Linfu ,
  • Xiao Wei ,
  • Liang Jingyu ,
  • Guo Yuewei
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  • a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203;
    b Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009;
    c Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001

Received date: 2013-04-25

  Revised date: 2013-06-09

  Online published: 2013-06-09

Supported by

Project supported by the National Marine "863" Project (Nos.2011AA09070102, 2013AA092902), the Natural Science Foundation of China (Nos.81273430, 21072204, 21021063), the Projects of State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (Nos.SIMM1203ZZ-03, SIMM1105KF-04), and the EU 7th Framework Program-IRSES (International Research Staff Exchange Scheme) Project (2010~2014).

摘要

二聚西松烷型二萜(biscembranoid)是一类骨架新颖、结构复杂、罕见的海洋天然产物, 主要存在于肉芝软珊瑚属珊瑚生物中.这类化合物多具有显著的生物活性, 尤其表现为抗炎、抗肿瘤等.对近年来报道的肉芝软珊瑚属中的二聚西松烷型二萜化合物的化学及生物活性进行综述, 并对其药用前景作出展望.

本文引用格式

李玉芬 , 梁林富 , 萧伟 , 梁敬钰 , 郭跃伟 . 肉芝软珊瑚属中二聚西松烷型二萜化合物的化学和生物活性研究进展[J]. 有机化学, 2013 , 33(06) : 1157 -1166 . DOI: 10.6023/cjoc201304044

Abstract

Biscembranoides, a kind of novel and complex compounds, mainly exist in the soft corals of the genus sarcophyton exhibiting good biological activities in drug discovery, especially for the activities of anti-inflammatory, antitumor, etc.In this review, we focus on the progress in chemical and bioactive research of biscembranoides in recent years and their prospections in the future.

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