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2013 , Vol. 33 >Issue 10: 2220 - 2225

DOI: https://doi.org/10.6023/cjoc201304037

研究简报

5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺类化合物的微波合成

  • 孙宏顺 ,
  • 王建强 ,
  • 郭成 ,
  • 沈临江
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  • a 南京工业大学理学院 南京 211816;
    b 南京化工职业技术学院化学工程系 南京 210048

收稿日期: 2013-04-23

  修回日期: 2013-05-28

  网络出版日期: 2013-07-03

基金资助

国家自然科学青年基金(No. 21106069)、南京化工职业技术学院院级重点(No. NHKY-2013-2)资助项目

收起

Synthesis of 5-Amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carboxamide Derivatives under Microwave Irradiation

  • Sun Hongshun ,
  • Wang Jianqiang ,
  • Guo Cheng ,
  • Shen Linjiang
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  • a Nanjing University of Technology, Nanjing 211816;
    b Nanjing College of Chemical Technology, Nanjing 210048

Received date: 2013-04-23

  Revised date: 2013-05-28

  Online published: 2013-07-03

Supported by

Project supported by the National Natural Science Foundation of China (No. 21106069) and the Key Program of Nanjing College of Chemical Technology (No. NHKY-2013-2).

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摘要

以芳亚甲基丙二腈、2,4-噻唑烷二酮和醋酸铵为原料, 在微波辐射条件下, 合成得到5种未见文献报道的5-胺 基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺系列化合物. 发现微波辐射条件下与传统加热条件下所得产物5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲腈不同, 并对反应机理进行了探讨. 所有新化合物结构均经1H NMR, IR, MS和元素分析确证.

关键词： 2,4-噻唑烷二酮; 噻唑并[4,5-b]吡啶; 微波; 合成

本文引用格式

孙宏顺 , 王建强 , 郭成 , 沈临江 . 5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺类化合物的微波合成[J]. 有机化学, 2013 , 33(10) : 2220 -2225 . DOI: 10.6023/cjoc201304037

Abstract

Five new 5-amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carboxamide derivatives, which are different with the products of 5-amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carbonitrile derivatives in the conventional heating conditions, were synthesized by using arylmethylene malononitrile, 2,4-thiazolidinedione and ammonium acetate in one-pot via microwave irradiation techniques. And the reaction mechanism was discussed. The structures of these compounds were characterized by 1H NMR, IR, MS and elemental analysis.

Key words： 2,4-thiazolidinedione; thiazolo[4,5-b]pyrirnidine; microwave irradiation; synthesis

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