含1-甲基环己基的酰基硫脲类化合物合成及除草活性
收稿日期: 2013-05-14
修回日期: 2013-06-27
网络出版日期: 2013-07-10
基金资助
“十二五”国家科技支撑计划（No. 2011BAE06B03-01）资助项目.
Synthesis and Herbicidal Activities of 1-Methylcyclohexyl-formayl Thioureas
Received date: 2013-05-14
Revised date: 2013-06-27
Online published: 2013-07-10
Supported by
Project supported by the The Twelfth Five-Year National Key Technology R & D Project (No. 2011BAE06B03-01).
贡云芸 , 黄伟 , 刘幸海 , 翁建全 , 谭成侠 . 含1-甲基环己基的酰基硫脲类化合物合成及除草活性[J]. 有机化学, 2013 , 33(11) : 2396 -2401 . DOI: 10.6023/cjoc201305024
In order to find out novel pesticide lead compounds with good biological activity, totally 24 novel 1-methylcyclo-hexyl-formyl thiourea compounds were synthesized by the reaction of 1-methylcyclohexane-carbonyl chloride with various substituted amines. Their structures were confirmed by 1H NMR, MS, and elemental analysis. The biological activities of these compounds were evaluated. Most of the compounds showed good herbicide activities at the concentration of 200 mg/L.
Key words： 1-methylcyclohexyl; acyl thiourea; synthesis; herbicidal activity
[1] Tong,J.Y.; Shi,Y.X.; Liu,X.H.; Sun,N.B.; Li,B.J.Chin.J.Org.Chem.2012,32(12),2373 (in Chinese).(童建颖,石延霞,刘幸海,孙娜波,李宝聚,有机化学,2012,32(12),2373.)
[2] Zhang,X.Y.; Li,Y.S.; Weng,J.Q.; Tan,C.X.Chin.J.Org.Chem.2011,31(8),1295 (in Chinese).(张向阳,李永曙,翁建全,谭成侠,有机化学,2011,31(8),1295.)
[3] Peng,H; He,H.-W.Chin.J.Org.Chem.2007,27(4),502 (in Chinese).(彭浩,贺红武,有机化学,2007,27(4),502.)
[4] Sun,N.B.; Tong,J.Y.; Wu,H.K.Chin.J.Org.Chem.2013,33(1),101 (in Chinese).(孙娜波,童建颖,武宏科,有机化学,2013,33(1),101.)
[5] Liu,X.H.; Pan,L.; Weng,J.Q.; Tan,C.X.; Li,Y.H.; Wang,B.L.; Li,Z.M.Mol.Diversity 2012,16(2),251.
[6] Weng,J.Q.; Wang,L.; Liu,X.H.J.Chem.Soc.Pak.2012,34(5),1248.
[7] Liu,X.-F.; Liu,X.-H.Acta Crystallogr.,Sect.E 2011,67,O202.
[8] Liu,X.H.; Tan,C.X.; Weng,J.Q.Phosphorus,Sulfur Silicon Relat.Elem.2011,186,552.
[9] Liu,X.H.; Zhang,C.Y.; Guo,W.C.; Li,Y.H.; Chen,P.Q.; Wang,T.; Dong,W.L.; Wang,B.L.; Sun,H.W.; Li,Z.M.J.Enzyme Inhib.Med.Chem.2009,24,545.
[10] Zhang,J.W.; Li,Y.Q.; Yang,X.L.; Chen,L.L.; Miao,H.J.; Li,H.; Wang,X.W.; Ling,Y.Chin.J.Org.Chem.2013,33(2),305 (in Chinese).(张继伟,李永强,杨新玲,陈路路,苗宏健,李慧,王献伟,凌云,有机化学,2013,33(2),305.)
[11] Schroeder,D.C.Chem.Rev.1955,55(1),181.
[12] Marina,V.; Alexander,M.; Armando,J.Adv.Synth.Cat.2009,351,2936.
[13] Heinz,L.; Ingrid,M.; Christoph,R.Tetrahedron Lett.1981,22,2365.
[14] Liu,C.-L.Pesticide 2000,6,99 (in Chinese).(刘长令,农药,2000,6,99.)
[15] Fudan High Polymer University Polymer Chemistry,Fudan University Press,Shanghai,1995,p.95 (in Chinese).(复旦大学高分子教研室 高分子化学,复旦大学出版社,上海,1995,p.95.)
/
| 〈 |
|
〉 |
