新型含1,3,4-噻二唑的硫脲化合物的合成及除草活性
收稿日期: 2013-06-19
修回日期: 2013-07-19
网络出版日期: 2013-08-13
基金资助
“十二五”国家科技攻关计划(No. 2011BAE06B03-01)和浙江省重点科技创新团队(No. 2010R50018)资助项目.
Synthesis and Herbicidal Activity of New 1,3,4-Thiadizols Sulfourea Derivative
Received date: 2013-06-19
Revised date: 2013-07-19
Online published: 2013-08-13
Supported by
Project supported by the National Key Technologies R & D Program (No. 2011BAE06B03-01) and the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018).
孙召慧 , 黄伟 , 贡云芸 , 蓝健 , 刘幸海 , 翁建全 , 李永曙 , 谭成侠 . 新型含1,3,4-噻二唑的硫脲化合物的合成及除草活性[J]. 有机化学, 2013 , 33(12) : 2612 -2617 . DOI: 10.6023/cjoc201306028
To find new pesticidal lead compounds with high bioactivity, 18 acylthioureas contain 1,3,4-thiadizols were obtained by condensation between acyl isothiocyanate and 1,3,4-thiadiazols. Their structures were confirmed by 1H NMR and MS. The herbicidal activities of these compounds were evaluated. All the compounds have herbicidal activity at 200 g ai/ha. The bioassay results showed that compound 5b had 90% inhibitory effect against Echinochloa crusgalli, Setaira viridis, Digitaria sanguinalis, Amaranthus retroflexus and Eclipta prostrate at 200 g ai/ha in pre-emergence condition and 90% and 95% against Echinochloa crusgalli and Eclipta prostrate at 200 g ai/ha in post-emergence condition, respectively; and compound 5e had 100% inhibitory effect against Echinochloa crusgalli, Setaira viridis, Digitaria sanguinalis and Amaranthus retroflexus at 200 g ai/ha in post-emergence and post-emergence condition.
Key words： acyl thiourea; 1,3,4-thiadiazol; synthesis; herbicidal activity
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