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2013 , Vol. 33 >Issue 12: 2618 - 2621

DOI: https://doi.org/10.6023/cjoc201306031

研究简报

炭角菌Xylaria sp. 290代谢产物中两个新的海松烷型二萜

  • 徐培培 ,
  • 尤怀成 ,
  • 胡志钰 ,
  • 李瑶瑶 ,
  • 沈月毛
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  • a 山东大学生命科学学院 济南 250100;
    b 厦门大学生命科学学院 厦门 361005;
    c 山东大学药学院 济南 250012

收稿日期: 2013-06-20

  修回日期: 2013-07-09

  网络出版日期: 2013-08-13

基金资助

国家重点基础研究发展计划(973计划，No. 2010CB833802)资助项目.

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Two New Pimarane-Type Diterpenes from the Metabolites of Xylaria sp. 290

  • Xu Peipei ,
  • You Huaicheng ,
  • Hu Zhiyu ,
  • Li Yaoyao ,
  • Shen Yuemao
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  • a School of Life Sciences, Shandong University, Jinan 250100;
    b School of Life Sciences, Xiamen University, Xiamen 361005;
    c School of Pharmaceutical Sciences, Shandong University, Jinan 250012

Received date: 2013-06-20

  Revised date: 2013-07-09

  Online published: 2013-08-13

Supported by

Project supported by the Major State Basic Research Development Program of China (973 Program, No. 2010CB833802).

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摘要

从炭角菌属真菌290中分离得到两个新的海松烷型二萜xylarianes A (1)和B (2)，以及一个已知的该类二萜16-hydroxy isopimar-7-en-19-oic acid (3). 通过一维和二维NMR数据解析及高分辨率质谱分析确定了化合物1～3的化学结构. 化合物1～3 在抗肿瘤活性测定中均未显示出活性.

关键词： 海松烷; 二萜; 炭角菌属

本文引用格式

徐培培 , 尤怀成 , 胡志钰 , 李瑶瑶 , 沈月毛 . 炭角菌Xylaria sp. 290代谢产物中两个新的海松烷型二萜[J]. 有机化学, 2013 , 33(12) : 2618 -2621 . DOI: 10.6023/cjoc201306031

Abstract

Two new pimarane-type diterpenes, xylarianes A (1) and B (2), were isolated from the crude extract of the fungus Xylaria sp. 290 along with one known compound of 16-hydroxy-isopimar-7-en-19-oic acid (3). The chemical structures of 1～3 were elucidated by spectroscopic methods including 1D-NMR and 2D-NMR experiments and HR-ESIMS. The antitumor assay of compounds 1～3 showed that they have no activities.

Key words： pimarane; diterpene; Xylaria sp.

参考文献

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