三聚氯氰促进的咪唑并[1,2-a]吡啶类化合物的合成
收稿日期: 2013-07-03
修回日期: 2013-09-23
网络出版日期: 2013-10-11
Cyanuric Chloride-Promoted Synthesis of Imidazo[1,2-a]pyridines
Received date: 2013-07-03
Revised date: 2013-09-23
Online published: 2013-10-11
以三聚氯氰作为反应促进剂，在室温和CH3CN作为溶剂的条件下，利用取代2-氨基吡啶、醛和烷基异腈三组分缩合，高收率地实现了一系列咪唑并[1，2-a]吡啶类化合物的合成. 产物结构经1H NMR，13C NMR和元素分析等进行了表征.
关键词： 咪唑并[1,2-a]吡啶类化合物; 三聚氯氰; Groebcke 反应; 多组分反应; 合成
尹志奎 , 田拴宝 . 三聚氯氰促进的咪唑并[1,2-a]吡啶类化合物的合成[J]. 有机化学, 2014 , 34(2) : 387 -391 . DOI: 10.6023/cjoc201307004
Cyanuric chloride-promoted synthesis of imidazo[1,2-a]pyridine derivatives was realized in high yields by the reaction of 2-aminopyridines, aldehydes and isonitriles in CH3CN at room temperature. All products were characterized by 1H NMR, 13C NMR and elemental analysis.
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