1,3-二羟基呫吨酮类化合物的简洁合成及清除亚硝酸根作用研究
收稿日期: 2013-10-11
修回日期: 2013-11-10
网络出版日期: 2013-11-21
基金资助
国家自然科学基金（No. 81172982）；广东省科技计划社会发展重点（No. 2010A030100006）；新药研究国家重点实验室开放基金（No. SIMM1302KF-12）资助项目.
Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite
Received date: 2013-10-11
Revised date: 2013-11-10
Online published: 2013-11-21
Supported by
Project supported by the National Natural Science Foundation of China (No. 81172982), the Guangdong Provincial Project of Science and Technology (No. 2010A030100006) and the State Key Laboratory of Drug Research (No. SIMM1302KF-12).
毛双双 , 郑欢欢 , 罗翠婷 , 陈河如 . 1,3-二羟基呫吨酮类化合物的简洁合成及清除亚硝酸根作用研究[J]. 有机化学, 2014 , 34(3) : 515 -521 . DOI: 10.6023/cjoc201310010
Twelve 1,3-dihydroxylxanthones (3a～3l) were synthesized under the catalysis of Eaton's reagent applying phloroglucinol and substituted salicylic acids as starting materials. The yields were from 63% to 87%. The reaction mechanism and their structure-reaction activity relationship have been discussed. The clearance effections of all the prepared xanthones against nitrite have been investigated by UV spectrophotometry. It is disclosed that all the tested xanthones have obvious clearance effections against nitrite at the conditions of pH 3, room temperature, and 30 min treatment. 3b and 3f are identified as the most active compounds with clearance rate up to 34.0%. The clearance mechanism of xanthones against nitrite and their structure-activity relationships were also included here.
Key words： xanthones; organic synthesis; nitrite; cancer prevention; Eaton’s reagent
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