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2014 , Vol. 34 >Issue 4: 783 - 787

DOI: https://doi.org/10.6023/cjoc201309025

研究论文

1,4-二氢吡啶并[3,2-c]香豆素类衍生物的有效合成

  • 王道林 ,
  • 董哲 ,
  • 刘忠 ,
  • 赵伟 ,
  • 杨菲菲
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  • a 辽宁省功能化合物合成与应用重点实验室 渤海大学化学化工与食品安全学院 锦州 121003;
    b 吉林省石油化工设计研究院 长春 130021

收稿日期: 2013-09-16

  修回日期: 2013-12-04

  网络出版日期: 2013-12-13

基金资助

辽宁省科技厅（No. 2011220022）资助项目.

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Efficient One-Pot Synthesis of 1,4-Dihydropyridino[3,2-c]coumarins

  • Wang Daolin ,
  • Dong Zhe ,
  • Liu Zhong ,
  • Zhao Wei ,
  • Yang Feifei
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  • a Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003;
    b Jilin Research Institute of Petrochemical Technology, Changchun 130021

Received date: 2013-09-16

  Revised date: 2013-12-04

  Online published: 2013-12-13

Supported by

Project supported by the Science and Technology Department of Liaoning Province (No. 2011220022).

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摘要

在分子碘作用下，通过4-氨基香豆素、芳香醛和苯乙炔的三组分亚胺-环加成反应，成功制备了一系列1，4-二氢吡啶并[3，2-c]香豆素类化合物. 该反应操作简单、条件温和、收率良好. 产物结构经NMR，IR，MS及元素分析数据得以证实.

关键词： 4-氨基香豆素; 苯乙炔; 1,4-二氢吡啶并[3,2-c]香豆素; 亚胺-环加成反应; 碘; 合成

本文引用格式

王道林 , 董哲 , 刘忠 , 赵伟 , 杨菲菲 . 1,4-二氢吡啶并[3,2-c]香豆素类衍生物的有效合成[J]. 有机化学, 2014 , 34(4) : 783 -787 . DOI: 10.6023/cjoc201309025

Abstract

Efficient one-pot synthesis of 1,4-dihydropyridino[3,2-c]coumarines was obtained starting from 4-aminocou-marin, aromatic aldehydes and phenylacetylene via imino-Diels-Alder reaction in the presences of molecular iodine as a catalyst in good yields. All of above compounds have been confirmed by NMR, IR, MS spectra and elemental analysis.

Key words： 4-aminocoumarins; phenylacetylene; 1,4-dihydropyridino[3,2-c]coumarine; imino-Diels-Alder reaction; iodine; synthesis

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