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2014 , Vol. 34 >Issue 4: 761 - 766

DOI: https://doi.org/10.6023/cjoc201310038

研究论文

2-氯乙酰胺与硫脲绿色合成4-噻唑啉酮的反应研究

  • 赵华绒 ,
  • 王玲 ,
  • 王昱丹
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  • a 浙江大学化学系 杭州 310027;
    b 绍兴文理学院化学化工学院 绍兴 312000

收稿日期: 2013-10-25

  修回日期: 2013-12-05

  网络出版日期: 2013-12-19

基金资助

浙江省自然科学基金（Nos. LY12B02015，Y4080234）资助项目.

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A Novel and Green Method for the Synthesis of 4-Thiazolidinones with the Sources of 2-Chloroacetamide and Thioureas

  • Zhao Huarong ,
  • Wang Ling ,
  • Wang Yudan
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  • a Department of Chemistry, Zhejiang University, Hangzhou 310027;
    b College of Chemistry & Chemical Engineering, Shaoxing University, Shaoxing 312000

Received date: 2013-10-25

  Revised date: 2013-12-05

  Online published: 2013-12-19

Supported by

Project supported by the Natural Science Foundation of Zhejiang Province (Nos. LY12B02015, Y4080234).

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摘要

首次报道了一种在离子液体中以2-氯乙酰胺与取代硫脲为原料，脱氨合成4-噻唑啉酮类化合物的新方法，并对其机理进行了探讨. 通过实验表明该方法具有反应时间短，底物适应性广，原子经济性好，原料易得，收率较高，环境友好，产物易于分离纯化等特点，为4-噻唑啉酮类化合物的合成提供了一种新途径.

关键词： 4-噻唑啉酮; 2-氯乙酰胺; 离子液体; 机理; 绿色

本文引用格式

赵华绒 , 王玲 , 王昱丹 . 2-氯乙酰胺与硫脲绿色合成4-噻唑啉酮的反应研究[J]. 有机化学, 2014 , 34(4) : 761 -766 . DOI: 10.6023/cjoc201310038

Abstract

A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the sources of substituted thioureas and 2-chloroacetamide in the ionic liquids. This method offers several advantages like high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.

Key words： 4-thiazolidinones; 2-chloroacetamide; ionic liquid; mechanism; green

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