加兰他敏类生物碱的不对称合成研究进展
收稿日期: 2013-12-02
修回日期: 2014-01-07
网络出版日期: 2014-02-10
基金资助
国家自然科学基金（No. 21302061）、中国博士后科学基金（Nos. 2013T60318，2012M510130）和吉林省科技发展计划（No. 20140520084JH）资助项目.
Progress in Asymmetric Synthesis of Galanthamine-Type Alkaloids
Received date: 2013-12-02
Revised date: 2014-01-07
Online published: 2014-02-10
Supported by
Project supported by the National Natural Science Foundation of China (No. 21302061), the China Postdoctoral Science Foundation (Nos. 2013T60318, 2012M510130) and the Jilin Province Science and Technology Development Plan Item (No. 20140520084JH).
王海明 , 陈鹏 , 唐萌 . 加兰他敏类生物碱的不对称合成研究进展[J]. 有机化学, 2014 , 34(5) : 852 -864 . DOI: 10.6023/cjoc201312002
Galanthamine-type alkaloids are an important type of hydrodibenzofuran alkaloids. Their unique intriguing structures, significant biological activitives and pharmacological potential have attracted much attention of chemists and pharmacologists. The major challenge for their synthesis is how to construct the aryl-substituted all-carbon quaternary stereogenic center. In this paper, current strategies for asymmetric synthesis of galanthamine-type alkaloids are reviewed, and the different methods to prepare the quaternary carbon are discussed. The features of different strategies are also commented.
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