IPrAuCl/AgOTf催化下合成N-磺酰基四氢吡咯类化合物
收稿日期: 2013-12-19
修回日期: 2014-01-21
网络出版日期: 2014-02-14
基金资助
浙江省自然科学基金（No. Y4100558）资助项目.
Synthesis of N-Sulfonyl Pyrrolidines Catalyzed by IPrAuCl/AgOTf
Received date: 2013-12-19
Revised date: 2014-01-21
Online published: 2014-02-14
Supported by
Project supported by the Natural Science Foundation of Zhejiang Province (No. Y4100558).
原东鹏 , 曾明 , 柏春美 , 崔冬梅 , 张辰 . IPrAuCl/AgOTf催化下合成N-磺酰基四氢吡咯类化合物[J]. 有机化学, 2014 , 34(6) : 1231 -1234 . DOI: 10.6023/cjoc201312025
6-Bromofuro[2,3-d]pyrimidine bicyclic nucleosides are the key intermediates for the preparation of novel furo[2,3-d]pyrimidine bicyclic nucleoside derivatives with remarkable antiviral potency. The literature protocol for their synthesis involves a multi-step procedure and palladium catalyst. In this paper, an economical and practical method was developed for their preparation via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide and subsequent cyclization promoted by copper iodide.
Key words： sulfonamide; catalyst; tetrahydrofuran; pyrrolidine
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