新型含三氟甲基取代的邻苯二酰胺衍生物的设计、合成及生物活性研究
收稿日期: 2014-01-14
修回日期: 2014-03-03
网络出版日期: 2014-03-13
基金资助
国家重点基础研究发展计划（973计划，No.2010CB126106）、国家科技攻关计划（No.2011BAE06B05）、天津化学化工协同创新中心资助项目.
Design, Synthesis and Biological Activities of Novel Trifluoromethylated Phthalic Acid Diamides Derivatives
Received date: 2014-01-14
Revised date: 2014-03-03
Online published: 2014-03-13
Supported by
Project supported by the National Basic Research Program of China (973 Program, No. 2010CB126106), the National Key Technologies R&D Program (No. 2011BAE06B05), and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).
周莎 , 张秀兰 , 魏巍 , 刘敬波 , 熊丽霞 , 杨娜 , 李正名 . 新型含三氟甲基取代的邻苯二酰胺衍生物的设计、合成及生物活性研究[J]. 有机化学, 2014 , 34(7) : 1424 -1428 . DOI: 10.6023/cjoc201401023
In order to find efficient, eco-friendly lead compounds, 10 novel phthalic acid diamide derivatives containing two trifluoromethylated aromatic amine moieties were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, HRMS and elemental analysis. Their insecticidal activities against oriental armyworms and diamondback moths were also evaluated. The preliminary results of biological evaluation showed that most compounds exhibited moderate to high larvicidal activity. These results provided further insights into the relationship between the structures and biological activity.
Key words： fluorine; phthalic acid diamides; synthesis; insecticidal activity
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