缩醛与吲哚或苯并呋喃的烷基化反应
收稿日期: 2014-06-23
修回日期: 2014-08-10
网络出版日期: 2014-08-26
基金资助
国家自然科学基金(No.21172019)资助项目.
Alkylation of Indole and Benzofuran with Acetals
Received date: 2014-06-23
Revised date: 2014-08-10
Online published: 2014-08-26
Supported by
Project supported by the National Natural Science Foundation of China (No. 21172019).
刘宁宁 , 杨玲 , 杨蓓 , 王金棒 , 陈雪 , 武钦佩 . 缩醛与吲哚或苯并呋喃的烷基化反应[J]. 有机化学, 2014 , 34(12) : 2523 -2528 . DOI: 10.6023/cjoc201401038
Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.
Key words： benzofuran; indole; acetal; alkylation
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