AgOAc为氧化剂制备活性白藜芦醇二聚体衍生物
收稿日期: 2014-02-05
修回日期: 2014-03-19
网络出版日期: 2014-04-01
Preparation of Active Resveratrol Dimeric Derivatives by Oxidative Coupling Reaction Using AgOAc as Oxidant
Received date: 2014-02-05
Revised date: 2014-03-19
Online published: 2014-04-01
以白藜芦醇为原料，醋酸银为氧化剂在甲醇中进行氧化偶联反应获得了7个白藜芦醇二聚体衍生物1～7. 以光谱分析的方法分别确定了它们的结构和相对构型，并讨论了它们可能的形成机理. 其中，化合物3，4和5为新的二苯乙烯二聚体衍生物，化合物6和7为首次人工合成的天然产物. 所得化合物均进行了体外抗炎活性测试.
关键词： 醋酸银; 氧化偶联反应; 白藜芦醇二聚体衍生物; 抗炎活性
张元 , 王先分 , 侯琦 , 林明宝 , 姚春所 , 石建功 . AgOAc为氧化剂制备活性白藜芦醇二聚体衍生物[J]. 有机化学, 2014 , 34(5) : 886 -892 . DOI: 10.6023/cjoc201402006
Oxidative coupling reaction of resveratrol in methanol using silver acetate as oxidant gave seven resveratrol dimeric derivatives 1～7. Their structures and relative configurations were determined on the basis of spectral analysis, and their formation mechanisms were discussed, respectively. Among them, compounds 3, 4 and 5 were determined as new stilbene dimers, and compounds 6 and 7 were synthesized as natural compounds for the first time. All the compounds were evaluated for anti-inflammatory activities.
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(卜鹏滨, 里艳茹, 姜明, 王晓良, 王芳, 林生, 朱承根, 石建功, 中国中药杂志, 2013, 38, 13.)
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