多肽酰肼法合成Nesiritide
收稿日期: 2014-01-24
修回日期: 2014-03-22
网络出版日期: 2014-04-02
基金资助
国家自然科学基金（Nos.21102083；21372058）资助项目.
Synthesis of Nesiritide via Ligation of Peptide Hydrazide
Received date: 2014-01-24
Revised date: 2014-03-22
Online published: 2014-04-02
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 201102083, 21372058).
Nesiritide是一类重要的多肽类血管扩张药物，在维持心血管和肾脏的体内平衡方面发挥着重要的作用. 目前，Nesiritide的合成主要是通过基因重组表达法获得，该方法操作较为复杂且存在一定的限制. 本研究运用多肽固相合成及酰肼连接策略，通过3片段连接高效合成了Nesiritide，为大批量工业化生产该类多肽药物打下基础.
关键词： 多肽酰肼连接; 自然化学连接; 多肽硫酯; Nesiritide
陈晨晨 , 李思践 , 陈轶群 , 许华建 , 李宜明 . 多肽酰肼法合成Nesiritide[J]. 有机化学, 2014 , 34(7) : 1452 -1457 . DOI: 10.6023/cjoc201401039
Nesiritide is an important class of peptide vasodilator. It plays a significant role in the maintenance homeostasis of cardiovascular and kidney. Nowadays, nesiritide is mainly obtained by biological methods including gene recombinant expression, which is relative time-consuming. In present work, the chemical synthesis of nesiritide was reported by using (solid-phase peptide synthesis) (SPPS) strategy combining with the ligation of peptide hydrazides with high yield and purity. Therefore, it was considered that the method presented here provided a convinced alternative for acquiring pharmaceutical peptide in a large scale.
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