CuBr2催化的三组分反应合成喹啉-2,4-二羧基衍生物
收稿日期: 2014-01-13
修回日期: 2014-03-12
网络出版日期: 2014-04-15
基金资助
云南省科技厅应用基础研究计划（No.2011FZ097）资助项目.
CuBr2-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives
Received date: 2014-01-13
Revised date: 2014-03-12
Online published: 2014-04-15
Supported by
Project supported by the Applied Basic Research Plan of Yunnan Province Science and Technology Department (No. 2011FZ097).
以廉价的CuBr2为催化剂，发展了一种通过芳胺、乙醛酸酯与丙酮酸酯三组分反应制得喹啉-2，4-二羧基衍生物的简便有效方法. 该方法具有很好的原子经济性，使用了便宜的催化剂和易得的试剂，在温和的条件下解决了以往喹啉-2，4-二羧基衍生物合成条件苛刻、产率低等问题，在生物活性分子和药物分子合成上有潜在的应用价值.
关键词： 喹啉-2,4-二羧基衍生物; 芳胺; 乙醛酸酯; 丙酮酸酯; CuBr2
王扣 , 于浩飞 , 丁林芬 , 胡建林 . CuBr2催化的三组分反应合成喹啉-2,4-二羧基衍生物[J]. 有机化学, 2014 , 34(7) : 1437 -1441 . DOI: 10.6023/cjoc201401020
A convenient and efficient method for synthesizing quinoline-2,4-dicarboxyl derivatives has been developed via a simple one-pot reaction of aromatic amines, glyoxylic ester, and pyruvate using low-costing CuBr2 as a catalyst. The method is atom efficiency, and utilizes non-expensive catalysts and easily available reagents, which provides an attractive approach to quinoline-2,4-dicarboxyl derivatives. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.
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