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2014 , Vol. 34 >Issue 8: 1682 - 1686

DOI: https://doi.org/10.6023/cjoc201402001

研究简报

碘催化下离子液体中2-苯基-2-苯甲酰基喹唑啉衍生物的合成

  • 张梅梅 ,
  • 刘蕴 ,
  • 王香善
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  • a 江苏省药用植物生物技术重点实验室 江苏师范大学 徐州 221116;
    b 江苏师范大学化学化工学院 徐州 221116

收稿日期: 2014-02-01

  修回日期: 2014-04-01

  网络出版日期: 2014-04-16

基金资助

国家自然科学基金（No.20802061）和江苏省高校产业化基金（No.JHB2013-31）资助项目.

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Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

  • Zhang Meimei ,
  • Liu Yun ,
  • Wang Xiangshan
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  • a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
    b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2014-02-01

  Revised date: 2014-04-01

  Online published: 2014-04-16

Supported by

Project supported by the National Natural Science Foundation of China (No. 20802061) and the College Industrialization Project of Jiangsu Province (No. JHB2012-31).

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摘要

介绍了一种以离子液体为绿色介质合成2，3-二氢化-2-苯基-2-苯甲酰基喹唑啉-4-酮衍生物的方法. 该方法是碘催化下的2-氨基苯甲酰胺和二苯基乙二酮反应，产物2，3-二氢化-2-苯基-2-苯甲酰基-3-苯乙基喹唑啉-4-酮（3f）的结构通过X射线衍射分析确证.

关键词： 喹唑啉-4-酮; 2-氨基苯甲酰胺; 二苯基乙二酮; 离子液体; 碘

本文引用格式

张梅梅 , 刘蕴 , 王香善 . 碘催化下离子液体中2-苯基-2-苯甲酰基喹唑啉衍生物的合成[J]. 有机化学, 2014 , 34(8) : 1682 -1686 . DOI: 10.6023/cjoc201402001

Abstract

A green method for the synthesis of 2,3-dihydro-2-benzoyl-2-phenylquinazolin-4(1H)-one derivatives, is described in high yields using ionic liquids as green media. The method involves a reaction of 2-aminobenzamide and benzil catalyzed by iodine. The structure of the product 2-benzoyl-3-phenethyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one (3f) was confirmed by X-ray diffraction analysis.

Key words： quinazolin-4(1H)-one; 2-aminobenzamide; benzil; ionic liquid; iodine

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