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2014 , Vol. 34 >Issue 8: 1662 - 1668

DOI: https://doi.org/10.6023/cjoc201402035

研究简报

含肟醚的姜黄素衍生物的合成及生物活性研究

  • 陈玉 ,
  • 王忠波 ,
  • 张贤 ,
  • 夏丽娟 ,
  • 龚华玉 ,
  • 赵洪菊 ,
  • 薛伟
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  • 贵州大学精细化工研究开发中心 绿色农药与农业生物工程国家重点实验室培育基地 教育部绿色农药与生物工程重点实验室 贵阳 550025

收稿日期: 2014-02-27

  修回日期: 2014-04-30

  网络出版日期: 2014-05-05

基金资助

国家十二五科技支撑计划（No.2011BAE06B04-09）和贵州大学研究生创新基金（No.2013036）资助项目.

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Synthesis and Biological Activity of Oxime Ethers of Curcumin Derivatives

  • Chen Yu ,
  • Wang Zhongbo ,
  • Zhang Xian ,
  • Xia Lijuan ,
  • Gong Huayu ,
  • Zhao Hongju ,
  • Xue Wei
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  • State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Received date: 2014-02-27

  Revised date: 2014-04-30

  Online published: 2014-05-05

Supported by

Project supported by the National Tweifth Five-Year Plan for Science and Technology (No. 2011BAE06B04-09) and the Innovation Fund for Graduate Student of Guizhou University (No. 2013036)

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摘要

采用活性拼接原理，将肟醚引入到含杂环的姜黄素衍生物1，4-戊二烯-3-酮结构中，合成了一系列新的1-芳基-5-杂环-1，4-戊二烯-3-酮肟醚类化合物，其结构经IR，1H NMR，13C NMR，ESI-MS和元素分析确认. 初步生物活性测试结果表明：在药剂浓度为500 μg/mL时，目标化合物具有一定的抗烟草病毒（TMV）活性.

关键词： 姜黄素; 肟醚; 合成; 抗TMV活性

本文引用格式

陈玉 , 王忠波 , 张贤 , 夏丽娟 , 龚华玉 , 赵洪菊 , 薛伟 . 含肟醚的姜黄素衍生物的合成及生物活性研究[J]. 有机化学, 2014 , 34(8) : 1662 -1668 . DOI: 10.6023/cjoc201402035

Abstract

On the principle of biologically active factor splicing, curcumin derivatives introduced active functional group oxime ethers into the structure of 1,4-pentadien-3-one. A series of new 1-phenyl-5-heterocycle-1,4-pentadien-3-one oxime ethers were synthesized, and their structures were identified by IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis. The preliminary bioassay results indicated that target compounds showed certain antiviral activity against TMV at a concentration of 500 μg/mL.

Key words： curcumin; oxime ether; synthesis; anti-TMV activity

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