铜催化一锅法合成吡咯[1,2-a]喹喔啉衍生物
收稿日期: 2014-03-10
修回日期: 2014-04-17
网络出版日期: 2014-05-06
基金资助
国家自然科学基金(No. 21072095)和江苏省研究生创新工程(No. CXLX13_433)资助项目.
One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives through Copper-Catalyzed Cascade Reactions
Received date: 2014-03-10
Revised date: 2014-04-17
Online published: 2014-05-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 21072095), the Graduate Student Innovation Project in Jiangsu Province (No. CXLX13_433).
建立了一种简单实用、经济高效的以邻碘苯胺、吡咯甲醛为起始原料，廉价的CuI为催化剂，价廉、易获得的2，2-联吡啶为配体，110 ℃条件下一锅法合成吡咯[1，2-a]喹喔啉类衍生物的催化体系，得到中等到优良产率. 本方法具有催化剂廉价易得、操作简便、合成效率高的优点.
关键词： 一锅法合成; 吡咯[1,2-a]喹喔啉; 铜催化
蒋增强 , 张杰 , 童耀 , 史雪松 , 苗大状 , 韩世清 . 铜催化一锅法合成吡咯[1,2-a]喹喔啉衍生物[J]. 有机化学, 2014 , 34(9) : 1845 -1850 . DOI: 10.6023/cjoc201403022
A simple, efficient, inexpensive one-pot method for the pyrrolo[1,2-a]quinoxaline derivatives synthesized from 2-formylazoles and o-aminoiodoarenes was developed by using cheap CuI as catalyst, inexpensive and readily available 2,2'-bipyridine as ligand at 110 ℃. The reaction provides an efficient protocol to a series of pyrrolo[1,2-a]quinoxaline derivatives in good to high yields, and benefits of readily available catalyst and synthesis of high efficiency.
Key words： one-pot synthesis; pyrrolo[1,2-a]quinoxalines; copper-catalyst
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