金催化炔烃与1,4-二氧六环的开环加成反应研究
收稿日期: 2014-03-28
修回日期: 2014-04-20
网络出版日期: 2014-05-06
基金资助
湖南省科技厅基金(No. 2012FJ3039)和湖南省教育厅科学研究(No. 13C236)资助项目.
Gold-Catalyzed Alkynes Ring-Opening Addition Reaction with Dioxane
Received date: 2014-03-28
Revised date: 2014-04-20
Online published: 2014-05-06
Supported by
Project supported by the Department of Science and Technology Foundation of Hunan Province (No. 2012FJ3039) and the Scientific Research Fund of Hunan Provincial Education Department (No. 13C236).
鄢东 , 吴超 , 易卫国 . 金催化炔烃与1,4-二氧六环的开环加成反应研究[J]. 有机化学, 2014 , 34(9) : 1857 -1863 . DOI: 10.6023/cjoc201403062
A simple and efficient method for the ring-opening addition reaction of terminal alkyne with dioxane catalyzed by XphosAuCl/AgNTf2 was developed in presence of 8-ethylquinoline-N-oxide and methanesulfonic acid. A series of carbonylethoxy ethyl methanesulfonates were synthesized in good yield. The high atom economy, mild reaction system and a wide range of tolerated substrates make the reaction very practical.
Key words： gold catalyst; alkyne; ring-opening reaction; α-oxo gold carbene
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