3,5-二取代的异噁唑啉类衍生物的合成及杀菌活性研究
收稿日期: 2014-03-11
修回日期: 2014-04-19
网络出版日期: 2014-05-07
基金资助
国家自然科学青年基金(No. 21205086)资助项目.
Synthesis and Fungicidal Activity of Some 3,5-Disubstituted Isoxazoline Derivatives
Received date: 2014-03-11
Revised date: 2014-04-19
Online published: 2014-05-07
Supported by
Project supported by the National Natural Science Foundation of China (No. 21205086).
宁国慧 , 赵温涛 , 边强 , 唐向阳 . 3,5-二取代的异噁唑啉类衍生物的合成及杀菌活性研究[J]. 有机化学, 2014 , 34(9) : 1800 -1805 . DOI: 10.6023/cjoc201403026
Various substituted benzaldehydes reacted with hydroxylamine hydrochloride, followed by the chlorination with N-chlorosuccinimide (NCS), to form the corresponding chlorobenzaldehyde oximes, which then underwent the 1,3-dipolar cycloaddition reaction with N-vinylpyrrolidone, N-vinylpyridine and 4-vinylpyridine, respectively, to generate fifteen novel compounds containing isoxazoline ring. All the title compounds have been characterized by 1H NMR, 13C NMR, and HRMS. Preliminary biological activity tests in vitro indicated that compounds 3e～3o displayed excellent fungicidal activity against C. arachidicola, P. piricola, A. solani, F. graminearum, P. capsici, S. sclerotiorum, and R. solani in the test concentration, compound 3b displayed excellent fungicidal activity against B. cinerea, and compound 3c displayed excellent fungicidal activity against A. solani, C. arachidicola and S. Sclerotiorum.
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