具有特殊甾核结构甾体化合物的合成及生理活性研究进展
收稿日期: 2014-03-18
修回日期: 2014-04-21
网络出版日期: 2014-05-07
基金资助
广西省自然科学基金(Nos. 2012GXNSFAA053018, 2012GXNSFAA053018)及广西高等科学技术研究(No. 200103YB067)资助项目.
Recent Advance of Synthesis and Bioactivities for Steroids with Special Steroidal Nucleus
Received date: 2014-03-18
Revised date: 2014-04-21
Online published: 2014-05-07
Supported by
Project supported by the Natural Science Foundation of Guangxi Province (Nos. 2012GXNSFAA053018, 2012GXNSFAA053018) and the Scientific and Technology Research Funding of Guangxi University (No. 200103YB067).
改变甾体的甾核结构，在甾核或支链中引入不同的官能团，可以得到一些具有不同生理活性的化合物. 按照不同类型甾核结构分类，结合本课题组在具有特殊甾核结构甾体化合物的合成和生理活性研究方面所取得的一些成果，对近年来具有A-失碳甾体化合物、B-失碳甾体化合物及C-失碳-D-增碳甾体化合物的合成及生理活性进行讨论，并展望了此类化合物的发展趋势及应用前景.
关键词： 特殊甾核; A-失碳甾体化合物; B-失碳甾体化合物; C-失碳-D-增碳甾体化合物
甘春芳 , 盛海兵 , 戚斌斌 , 杨雷 , 赵丹丹 , 黄燕敏 , 崔建国 . 具有特殊甾核结构甾体化合物的合成及生理活性研究进展[J]. 有机化学, 2014 , 34(9) : 1730 -1742 . DOI: 10.6023/cjoc201403040
By changing the structure of steroidal nucleus, or introducing different functional groups into steroids, some steroidal compounds with various bioactivities might be obtained. In this paper, according to the different types of steroid nucleus structure, combining with the results of our research in steroids with special steroidal nucleus, the advance of synthesis and biological activities for A-nor steroids, B-nor steroids and C-nor-D-homo-steroids is discussed in recent years, and the development trend and application prospect are forecasted.
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