室温下铜催化制备含羰基或酯基的喹唑啉-4(3H)-亚基类衍生物
收稿日期: 2014-02-08
修回日期: 2014-04-28
网络出版日期: 2014-06-03
基金资助
国家自然科学基金（No. 21272266）和国家“十二五”科技支撑计划课题（No. 2011BAE06B05-5）资助项目.
Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature
Received date: 2014-02-08
Revised date: 2014-04-28
Online published: 2014-06-03
Supported by
Project supported by the National Natural Science Foundation of China (No. 21272266) and the National "Twelfth Five-Year" Plan for Science & Technology (No. 2011BAE06B05-5).
谢瑞龙 , 杨新玲 , 秦耀果 , 谭晓庆 , 凌云 . 室温下铜催化制备含羰基或酯基的喹唑啉-4(3H)-亚基类衍生物[J]. 有机化学, 2014 , 34(10) : 2076 -2082 . DOI: 10.6023/cjoc201402009
At room temperature, a new simple and efficient copper-catalyzed method for the synthesis of quinazolin- 4(3H)-ylidene derivatives containing carbonyl and ester group was developed. The targets were prepared using methyl 3-(2-bromophenyl)-3-oxopropanoate analogues and amidine hydrochlorides as the initial materials, cuprous iodide as catalyst, and potassium phosphate as base at the ligand-free condition. Their structures were confirmed by 1H NMR, 13C NMR and HRMS.
Key words： copper; room temperature; catalyst; quinazoline
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