瓜环/麦穗宁超分子体系的形成对麦穗宁的pKa、溶解性及抑菌活性的影响
收稿日期: 2014-03-07
修回日期: 2014-05-14
网络出版日期: 2014-07-01
基金资助
国家自然科学基金(No.21202026)、教育部春晖计划(No.Z2011034)、贵州省科技厅国际合作(No.黔科合外G字[2012]7003号)、贵州省英才培育(No.2012154)资助项目.
Influences on Shift of pKa, Solubility and Antifungal Activity ofFuberidazole by Inclusion Complexation with Cucurbit[n]urils
Received date: 2014-03-07
Revised date: 2014-05-14
Online published: 2014-07-01
Supported by
Project supported by the National Natural Science Foundation of China (No.21202026), the Ministry of Education Chuihui Plan (No.Z2011034), the Department of International Cooperation Projects of Guizhou Province (No.[2012]7003), and the Talent Cultivation Project of Guizhou Province (No.2012154).
郭改英 , 唐青 , 黄英 , 陶朱 , 薛赛凤 , 祝黔江 . 瓜环/麦穗宁超分子体系的形成对麦穗宁的pKa、溶解性及抑菌活性的影响[J]. 有机化学, 2014 , 34(11) : 2317 -2323 . DOI: 10.6023/cjoc201403020
Interaction between cucurbit[n]uril (Q[n], n=6, 7, 8) and fuberidazole (FBZ) in HCl solution at pH 2.5 was investigated by UV-Vis spectroscopy, ITC, 1H NMR spectroscopy. The shift of pKa and bioactivities against Fusarium graminearum about fuberidazole and its host-guest inclusion complexes were discussed. The results showed that the inclusion complexes between cucurbit[n]urils and fuberidazole were formed, and the corresponding pKa of complexes have shifted. In addition, complexation by Q[n] (n=6, 7, 8) has proven to cause solubility enhancement. The activity experimental results showed that complexation of fuberidazole with Q[n] (n=6, 7) recedes activity against Fusarium graminearum while with Q[8] enhances the activity against Fusarium graminearum in vivo.
Key words： cucurbit[n]urils; fuberidazole; spectroscopy; ITC; bioactivities
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