含噻唑骨架的吲哚衍生物的有效合成
收稿日期: 2014-07-10
修回日期: 2014-09-03
网络出版日期: 2014-09-25
基金资助
国家自然科学基金(No. 21476028)和辽宁省自然科学基金(No. 20120201)资助项目.
A Facile Synthesis of Thiazole Skeleton-Containing Indole Derivatives
Received date: 2014-07-10
Revised date: 2014-09-03
Online published: 2014-09-25
Supported by
Project supported by the National Natural Science Foundation of China (No. 21476028) and the Natural Science Foundation of Liaoning Province (No. 20120201).
高文涛 , 兰帅 , 郑宏梅 , 白仁青卓玛 . 含噻唑骨架的吲哚衍生物的有效合成[J]. 有机化学, 2015 , 35(1) : 144 -151 . DOI: 10.6023/cjoc201407014
An efficient and easy method for the synthesis of thiazole-containing indole derivatives was described, involving the condensation reaction of 5-chloroacetyloxindole with thiourea (substituted thiourea) and thioamide in the solvent of absolute ethanol via Hantzseh reaction to give the corresponding 5-(2-substituted-thiazol-4-yl)indolin-2-one (2a～2k) and 5-(2-substituted-thiazol-4-yl)indolin-2-one (2l～2q), respectively. The procedure has the advantages of simple operation, mild reaction conditions, and good yields. All of compounds were new and their structures were confirmed by IR, MS, P1PH NMR and P13PC NMR spectra and elemental analyses.
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