新型含氯代噻唑基团和嘧啶环的吡唑肟醚类衍生物的合成及其生物活性研究
收稿日期: 2014-08-03
修回日期: 2014-09-26
网络出版日期: 2014-10-13
基金资助
国家自然科学基金(Nos. 20772067, 21472102)资助项目.
Synthesis and Biological Activity Evaluation of Novel Pyrazole Oxime Ether Derivatives Containing Chlorothiazole Group and Pyrimidine Rings
Received date: 2014-08-03
Revised date: 2014-09-26
Online published: 2014-10-13
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 20772067, 21472102).
杨亚喆 , 林大勇 , 傅翠蓉 , 邹小毛 . 新型含氯代噻唑基团和嘧啶环的吡唑肟醚类衍生物的合成及其生物活性研究[J]. 有机化学, 2015 , 35(1) : 100 -108 . DOI: 10.6023/cjoc201408004
On the basis of our previous work, in order to seeking for novel compounds with bioactivities to settle for the resistance problem, two series of novel pyrazole oxime ether derivatives have been designed and synthesized containing chlorothiazole group and pyrimidine rings applying the bioisosterism. Their structures were determined by 1H NMR, IR, elemental analysis and MS, and their bioactivities were performed. Nearly half of the target compounds of series A with chlorothiazole group exhibited good insecticidal activity against culex pipiens pallens (100%, 5 mg·L-1), several compounds of series A showed good activity against Aphis laburni Kaltenbach (100%, 200 mg/L) and Tetranychus cinnabarinus (100%, 200 mg/L), and the compounds of series B with pyrimidine rings exhibited certain fungicidal activity.
Key words： pyrazole oxime; chlorothiazole; pyrimidine rings; synthesis; bioactivity
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