含二氟甲基取代的吡唑酰胺类化合物的合成及杀菌活性
收稿日期: 2014-06-13
修回日期: 2014-09-22
网络出版日期: 2014-10-22
基金资助
“十二五”国家科技支撑计划(No. 2011BAE06B03-01)、浙江省重点科技创新团队(No. 2010R50018)资助项目.
Synthesis and Fungicidal Activity of Difluoromethy Substituted Carboxamide Derivatives
Received date: 2014-06-13
Revised date: 2014-09-22
Online published: 2014-10-22
Supported by
Supported by the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018), and the Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03-01).
刘婷婷 , 倪芸 , 钟良坤 , 黄红英 , 胡伟群 , 许天明 , 谭成侠 . 含二氟甲基取代的吡唑酰胺类化合物的合成及杀菌活性[J]. 有机化学, 2015 , 35(2) : 422 -427 . DOI: 10.6023/cjoc201406017
In the course of discovering novel fungicidal lead compounds with high activity and safety, 13 new difluoromethyl substituted carboxamide derivatives were designed and synthesized according to the principle of bioactive substructure combination. Their structures were confirmed by 1H NMR, MS and HRMS. The fungicidal activities of these compounds were evaluated. Preliminary bioassay showed that most of the title compounds showed good fungicidal activity at 200 mg/L.
Key words： isoxazole; pyrazole amides; synthesis; fungicidal activity
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