N-烃基-5-芳基吲哚-3-甲醛的合成和光谱性质
收稿日期: 2014-07-09
修回日期: 2014-09-28
网络出版日期: 2014-10-22
基金资助
广东省大学生创新(No. 1055912003)资助项目.
Syntheses and Spectral Properties of N-Alkyl-5-arylindole-3-carboxaldehydes
Received date: 2014-07-09
Revised date: 2014-09-28
Online published: 2014-10-22
Supported by
Project supported by the University Student Innovative Program of Guangdong Province (No. 1055912003).
以5-溴吲哚为原料, 经甲酰化、烷基化、PdCl2(dppf)催化下的Suzuki偶联反应, 合成了系列N-烃基-5-芳基吲哚-3-甲醛. 考察了催化剂、碱试剂和溶剂的选择与用量, 以及反应物配比等因素对Suzuki偶联反应的影响. 测定了标题化合物在乙腈中的紫外-可见吸收光谱和荧光发射光谱.
关键词： N-烃基-5-芳基吲哚-3-甲醛; 光谱性质; Suzuki偶联反应; 合成
林志强 , 曾向潮 , 蒙玉霞 . N-烃基-5-芳基吲哚-3-甲醛的合成和光谱性质[J]. 有机化学, 2015 , 35(2) : 490 -496 . DOI: 10.6023/cjoc201407011
Using 5-bromoindole as raw material and PdCl2(dppf) as catalyst, N-alkyl-5-arylindole-3-carboxaldehydes were synthesized by the formylation, alkylation and Suzuki coupling reaction. The effects of catalysts, alkali reagents, solvents and the molar ratio of reactants on Suzuki coupling reaction have been surveyed. UV-Vis and fluorescence spectra of the title compounds in acetonitrile were also investigated.
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