溴呋啶及其类似物的合成新方法研究
收稿日期: 2014-10-24
修回日期: 2014-11-22
网络出版日期: 2014-12-09
基金资助
国家自然科学基金(Nos. 21172057, 21272058, 21202040)及教育部博士点基金(No. 20114104110005)资助项目.
New Synthesis of Brivudine and Its Analogs
Received date: 2014-10-24
Revised date: 2014-11-22
Online published: 2014-12-09
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172057, 21272058, 21202040), and the Research Fund for the Doctoral Program of Higher Education (No. 20114104110005).
李培源 , 张建瑞 , 郭胜海 , 张新迎 , 范学森 . 溴呋啶及其类似物的合成新方法研究[J]. 有机化学, 2015 , 35(4) : 910 -916 . DOI: 10.6023/cjoc201410034
In this paper, a simple and practical method for the preparation of brivudine (BVDU) and its analog nucleoside derivatives via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide followed by an efficient and stereoselective debromination promoted by diethyl phosphite and triethylamine is presented.
Key words： brivudine; gem-dibromoalkenes; debromination
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