微波辅助无溶剂合成3-三氟乙酰基香豆素类化合物
收稿日期: 2014-11-08
修回日期: 2014-12-13
网络出版日期: 2015-01-06
基金资助
河南省教育厅基金(Nos.2009A150012,2011A210018)、国家自然科学基金(No.21102037)、河南省科技攻关项目基金(No.112101110200)资助项目.
Microwave Assisted Solvent-Free Synthesis of 3-(Trifluoroacetyl)coumarins
Received date: 2014-11-08
Revised date: 2014-12-13
Online published: 2015-01-06
Supported by
Project supported by the Education Foundation of Henan Province (Nos.2009A150012, 2011A210018), the National Natural Science Foundation of China (No.21102037), and the Key Science and Technology Foundation of Henan Province (No.112101110200).
以2-羟基-2-三氟甲基-2H-苯并吡喃-3-甲酸乙酯类化合物为原料, 在微波辅助和无溶剂的条件下进行再成环反应, 合成了一系列3-三氟乙酰基香豆素类化合物. 该方法具有反应时间短、产率高(73%~88%)、操作简单和环境友好等优点. 产物结构使用IR、NMR、HRMS和X射线单晶衍射仪进行确定.
关键词： 微波; 3-三氟乙酰基香豆素; 再成环反应; 无溶剂
杨国玉 , 王彩霞 , 樊素芳 , 谢普会 , 金秋 , 徐翠莲 . 微波辅助无溶剂合成3-三氟乙酰基香豆素类化合物[J]. 有机化学, 2015 , 35(5) : 1173 -1178 . DOI: 10.6023/cjoc201411012
A series of 3-(trifluoroacetyl)coumarins were synthesized by recyclization of ethyl-2-hydroxy-2-trifluoromethyl-2H-chromene-3-carboxylates under microwave assisted solvent-free conditions. This method has the advantages of short reaction time, high yields (73%~88%), easy operation and environmental friendliness. The synthesized compounds were characterized by IR, NMR, HRMS and X-ray studies.
Key words： microwave; 3-(trifluoroacetyl)coumarins; recyclization; solvent-free
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