镁粉促进Weinreb酰胺和卤代烃的“一锅法”制备酮类反应研究
收稿日期: 2014-11-10
修回日期: 2014-12-11
网络出版日期: 2015-01-09
基金资助
国家自然科学基金(No.21462037)资助项目.
"One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder
Received date: 2014-11-10
Revised date: 2014-12-11
Online published: 2015-01-09
Supported by
Project supported by the National Natural Science Foundation of China (No.21462037).
探索了空气中镁粉促进Weinreb酰胺和卤代烃“一锅法”制备酮类化合物的反应. 研究发现一元Weinreb酰胺和卤代烃可在空气中镁粉直接促进下反应, 简单高效地得到了相应的酮类化合物. 二元Weinreb酰胺和卤代烃在不同的原料配比下反应, 得到羰基Weinreb酰胺或二酮类化合物. 本方法具有操作简便、合成效率高等优点, 为酮类化合物的制备提供了一种简单、高效的合成方法.
关键词： 一锅法; Weinreb酰胺; 羰基Weinreb酰胺; 二酮
王凤娇, 陆爱玲, 黄丹凤, 苏瀛鹏, 夏晓文, 徐艳丽, 王克虎, 胡雨来 . 镁粉促进Weinreb酰胺和卤代烃的“一锅法”制备酮类反应研究[J]. 有机化学, 2015 , 35(5) : 1046 -1051 . DOI: 10.6023/cjoc201411014
The “one-pot” reaction of Weinreb amides and halides promoted by magnesium powder was investigated under air atmosphere at room temperature. It was found that the Weinreb amides from monocarboxylic acid can react with halides to give corresponding ketones efficiently. Keto Weinreb amides or diketones can be obtained from the reaction of the Weinreb amides with halides under different reaction conditions. The method has the advantages of simple operation and high yields.
Key words： one-pot; Weinreb amides; keto Weinreb amides; diketones
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