锡粉促进下α-亚甲基-γ-氨基酸酯的合成
收稿日期: 2014-10-30
修回日期: 2015-01-08
网络出版日期: 2015-01-15
基金资助
国家自然科学基金(No.21462037)资助项目.
Synthesis of Ethyl α-Methylene-γ-amino Carboxylates Promoted by Tin Powder
Received date: 2014-10-30
Revised date: 2015-01-08
Online published: 2015-01-15
Supported by
Project supported by the National Natural Science Foundation of China (No.21462037).
探索了锡粉促进下, 以1,4-二氧六环为溶剂, 在室温条件下, 通过醛、芳胺和2-溴甲基丙烯酸乙酯的烯丙基化反应, 合成α-亚甲基-γ-氨基酸酯的方法. 该方法不需使用任何催化剂, 具有高效、环境友好、价格低廉和操作简便等特点.
关键词： 锡粉; 醛; 胺; α-亚甲基-γ-氨基酸酯; 烯丙基化
夏晓文 , 冀石龙 , 王凤娇 , 黄丹凤 , 王克虎 , 苏瀛鹏 , 胡雨来 . 锡粉促进下α-亚甲基-γ-氨基酸酯的合成[J]. 有机化学, 2015 , 35(5) : 1040 -1045 . DOI: 10.6023/cjoc201410044
An allylation reaction was explored for the synthesis of ethyl α-Methylene-γ-amino carboxylates by treating aldehydes, aryl amines and ethyl 2-(bromomethyl)acrylate with tin powder at room temperature in 1,4-dioxane. The method is highly efficient and environmentally benign with catalyst-free, low cost and concise manipulation.
Key words： tin powder; aldehydes; amines; ethyl α-Methylene-γ-amino carboxylates; allylation
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