嘧啶核苷-查尔酮杂化体的合成及其抗利什曼原虫活性研究
收稿日期: 2015-01-14
修回日期: 2015-02-11
网络出版日期: 2015-02-12
基金资助
国家自然科学基金(Nos. 21172057, 21272058, 21202040)、河南省高校科技创新人才支持计划(No. 15HASTIT005)及河南省高校科技创新团队支持计划(No. 15IRTSTHN003)资助项目.
Synthesis and Antileishmanial Activity of Pyrimidine Nucleoside- Chalcone Hybrids
Received date: 2015-01-14
Revised date: 2015-02-11
Online published: 2015-02-12
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172057, 21272058, 21202040), the Program for Science and Technology Innovation Talents in Universities of Henan Province (No. 15HASTIT005), and the Program for Innovative Research Team in Science and Technology in University of Henan Province (No. 15IRTSTHN003).
宰文静 , 蒋盼盼 , 张新迎 , Philippe M. Loiseau , 郭胜海 , 范学森 . 嘧啶核苷-查尔酮杂化体的合成及其抗利什曼原虫活性研究[J]. 有机化学, 2015 , 35(6) : 1335 -1341 . DOI: 10.6023/cjoc201501018
In this paper, a group of pyrimidine nucleoside-chalcone hybrids were conveniently prepared through condensing 5-formyl pyrimidine nucleosides with (substituted) acetophenones under the promotion of aqueous sodium hydroxide. The hybrid compounds were then evaluated as potential antileishmanial agents and some of them showed promisingly potent activities.
Key words： pyrimidine nucleosides; chalcones; hybrids; antileishmanial activity
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