金催化2-炔基芳基叠氮与羧酸串联反应合成3-吲哚酯
收稿日期: 2015-01-15
修回日期: 2015-03-17
网络出版日期: 2015-03-24
基金资助
国家自然科学青年基金(No. 21302096)、江苏省自然科学青年基金(No. BK20130962)、江苏高校优势学科建设工程(PAPD)和国家自然科学基金(No. 21372117)资助项目.
Gold-Catalyzed Tandem Reactions of 2-Alkynyl Arylazides and Carboxylic Acids for the Synthesis of 1H-Indol-3-yl Esters
Received date: 2015-01-15
Revised date: 2015-03-17
Online published: 2015-03-24
Supported by
Project supported by the Young National Natural Science Foundation of China (No. 21302096), the Young Natural Science Foundation of Jiangsu Province (No. BK20130962), the Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the National Natural Science Foundation of China (No. 21372117).
张小祥 , 孙小萍 , 张海飞 , 崔杏丽 , 马猛涛 . 金催化2-炔基芳基叠氮与羧酸串联反应合成3-吲哚酯[J]. 有机化学, 2015 , 35(7) : 1469 -1474 . DOI: 10.6023/cjoc201501020
1H-Indol-3-yl acetates are very important indole derivatives, which can be found in many bioactive compounds and natural products. In this work, 1H-indol-3-yl acetates were efficiently prepared via α-imino gold carbenes generated by gold-catalyzed reactions of 2-alkynyl arylazides. A very simple and general method for the synthesis of 1H-indol-3-yl acetates was provided after examining the substrates scope.
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