一种简便合成多取代呋喃的新方法
收稿日期: 2015-03-16
修回日期: 2015-03-30
网络出版日期: 2015-04-10
基金资助
国家自然科学基金(Nos. 21272119, 21121002)、湖北省自然科学基金(No. 2007ABA375)资助项目.
A Facile and New Synthetic Method of Polysubstituted Furans
Received date: 2015-03-16
Revised date: 2015-03-30
Online published: 2015-04-10
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21272119, 21121002), and the Natural Science Foundation of Hubei Province (No. 2007ABA375).
邹雯 , 贺峥嵘 , 贺峥杰 . 一种简便合成多取代呋喃的新方法[J]. 有机化学, 2015 , 35(8) : 1739 -1745 . DOI: 10.6023/cjoc201503022
With the treatment of tributylphosphine and base, alkynoates, aromatic aldehydes and acyl chlorides readily undergo a four-component cascade annulation reaction, giving tri-or tetra-substituted furans in moderate yields. The reaction presumably proceeds through an intramolecular Wittig reaction step of the in situ generated phosphorus ylide intermediate. The annulation reaction features mild reaction conditions and broad substrate scope, and accordingly constitutes a facile and new synthetic method of polysubstituted furans.
Key words： furans; synthesis; phosphines; multicomponent reactions; Wittig reaction
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