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2015 , Vol. 35 >Issue 9: 1991 - 1993

DOI: https://doi.org/10.6023/cjoc201504041

研究简报

铝盐促进的谷氨酸转氨化合成α-酮戊二酸的研究

  • 吴江 ,
  • 黄少胥
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  • 中国科学院上海有机化学研究所 上海 200032

收稿日期: 2015-04-27

  修回日期: 2015-05-11

  网络出版日期: 2015-05-15

基金资助

上海市自然科学基金(No. 13ZR1464900)资助项目.

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Aluminum(III) Salts Promoted Transamination of Glutamic Acid for the Synthesis of α-Ketoglutaric Acid

  • Wu Jiang ,
  • Huang Shao-Xu
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  • Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received date: 2015-04-27

  Revised date: 2015-05-11

  Online published: 2015-05-15

Supported by

Project supported by the Natural Science Foundation of Shanghai City (No. 13ZR1464900).

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摘要

报道了以铝盐为促进剂、通过对谷氨酸向乙醛酸水合物转氨化合成α-酮戊二酸的简便方法. 通过对反应条件的系统优化, 发现在少量简单铝盐KAl(SO4)2·12H2O存在下, 在pH＝5的水溶液中, 80 ℃下反应4 h, 能够方便地实现谷氨酸向乙醛酸的高效转氨化, α-酮戊二酸收率最高可达到87%. 该方法原料价廉易得、操作简便、产率优良、提供了一种α-酮戊二酸的高效、实用合成方法.

关键词： 谷氨酸; α-酮戊二酸; 转氨化

本文引用格式

吴江 , 黄少胥 . 铝盐促进的谷氨酸转氨化合成α-酮戊二酸的研究[J]. 有机化学, 2015 , 35(9) : 1991 -1993 . DOI: 10.6023/cjoc201504041

Abstract

This paper reports an efficient approach for the synthesis of α-ketoglutaric acid via Al(III) salt promoted transamination of glyoxylic acid monohydrate with glutamic acid. Under optimized conditions (80 ℃, pH＝5), the transamination proceeded efficiently in an aqueous solution of glyoxylic acid and glutamic acid in the presence of a catalytic amount of KAl(SO4)2·12H2O, affording α-ketoglutaric acid in up to 87% yield. This method features inexpensive chemical feedstocks, easy operation and high productivity, thus providing an efficient and practical approach to α-ketoglutaric acid.

Key words： glutamic acid; α-ketoglutaric acid; transamination

参考文献

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