含硅二烃基锡(IV)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性
收稿日期: 2015-03-03
修回日期: 2015-05-20
网络出版日期: 2015-05-26
基金资助
国家自然科学基金(No. 20762006)资助项目.
Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole
Received date: 2015-03-03
Revised date: 2015-05-20
Online published: 2015-05-26
Supported by
Project supported by the National Natural Science Foundation of China (No. 20762006).
合成了6个含硅二烃基锡(IV)的2-巯基苯并噻唑配合物R1R2SnL2 (R1＝Me3SiCH2, R2＝Me3SiCH2或Ph, Cy; R1＝EtMe2SiCH2, R2＝EtMe2SiCH2或Ph, Cy. LH＝2-硫基苯并噻唑), 并通过IR、1H NMR、13C NMR、元素分析和X射线单晶衍射对目标化合物进行结构表征. 结果表明, 配体L以硫醇互变异构体形式与锡原子配位, 形成了以锡为中心的六配位扭曲八面体结构; 生物活性试验的初步结果显示, 含硅二烃基锡(IV)-2-巯基苯并噻唑对肺腺癌细胞(A549)具有较强的体外抗癌活性.
廖启华 , 林森 , 邓瑞红 , 黄志强 , 邓柯玉 , 严兆华 . 含硅二烃基锡(IV)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性[J]. 有机化学, 2015 , 35(9) : 1923 -1928 . DOI: 10.6023/cjoc201503002
Six diorganotin(IV) complexes containing silicon of 2-mercaptobenzothiazole R1R2Sn(L)2 (R1＝Me3SiCH2, R2＝Me3SiCH2 or Ph, Cy; R1＝EtMe2SiCH2, R2＝EtMe2SiCH2 or Ph, Cy. LH＝2-mercaptobenzothiazole) have been synthesized and characterized by 1H NMR, 13C NMR, IR, elemental analysis and X-ray single-crystal study. The results showed that ligand L acts as thiol tautomerism coordinating with tin atom, and thus the central tin atom was six coordinated in distorted octahedral geometry. The preliminary bioassay tests showed that diorganotin complexes of 2-mercaptobenzothiazole have a good antitumor activity in vitro against A-549.
Key words： diorganotin; 2-mercaptobenzothiazole; complexes; synthesis; structure; antitumour activity
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