毛叶鹰爪花中一个新颖的裂环多氧取代环己烯类化合物
收稿日期: 2015-05-05
修回日期: 2015-05-25
网络出版日期: 2015-05-29
基金资助
国家自然科学基金(Nos. 31360069, 21302181)、海南省自然科学基金(No. 214027)、国际科技合作与交流专项(No. 2014DFA40850)、海南省应用技术研发与示范推广专项(No. ZDXM2015063)、海南省高校科研(No. HNKY2014-41)和国家大学生创新训练计划(Nos. 201411658031, 3010151053)资助项目.
A New Polyoxygenated Seco-cyclohexene Derivative from Artabotrys pilosus
Received date: 2015-05-05
Revised date: 2015-05-25
Online published: 2015-05-29
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 31360069, 21162009), the Natural Science Foundation of Hainan Province (No. 214027), the International S&T Cooperation Program of China (No. 2014DFA40850), the Major Technology Project of Hainan (No. ZDXM2015063), the Scientific Research Project of Hainan Colleges and Universities (No. HNKY2014-41) and the National Undergraduate Innovation Training Programs (Nos. 201411658031, 3010151053).
综合运用多种现代色谱学分离方法对毛叶鹰爪花中的化学成分进行了研究, 从其枝叶的乙醇提取物中分离得到了3个裂环多氧取代环己烯类化合物, 采用多种现代波谱技术确定了这些化合物的化学结构, 分别鉴定为artapilosol A (1), microcarpin A (2)和uvarisubol B (3). 其中化合物1为一个新化合物, 化合物2和3为首次从鹰爪花属植物中分离得到的化合物. 化合物1~3的体外细胞毒活性筛选结果表明它们对5种肿瘤细胞株(HL-60, A549, SMMC-7721, MCF-7和SW480)均显示出了较强的体外生长抑制活性, 它们的细胞毒活性与抗肿瘤阳性对照药顺铂相当.
关键词： 鹰爪花属; 毛叶鹰爪花; artapilosol A; 细胞毒活性
刘艳萍 , 黄丽刚 , 汪晓翠 , 文成全 , 许莎莎 , 宋小平 , 韩长日 , 陈光英 , 付艳辉 . 毛叶鹰爪花中一个新颖的裂环多氧取代环己烯类化合物[J]. 有机化学, 2015 , 35(9) : 1981 -1984 . DOI: 10.6023/cjoc201505007
A new polyoxygenated seco-cyclohexene derivative, artapilosol A (1), together with two known polyoxygenated seco-cyclohexene derivatives, microcarpin A (2) and uvarisubol B (3), was isolated from the stems and leaves of Artabotrys pilosus. Their structures were established on the basis of extensive spectral data. This is the first report that polyoxygenated seco-cyclohexene derivatives were isolated from the genus Artabotrys. Cytotoxicities of compounds 1~3 were tested against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Results showed that compounds 1~3 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.
Key words： Artabotrys; Artabotrys pilosus; artapilosol A; cytotoxicity
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