铜促C—H官能团化合成桥头氮稠杂环化合物的研究进展
收稿日期: 2015-04-11
修回日期: 2015-06-04
网络出版日期: 2015-06-12
基金资助
广东省引进创新科研团队计划(No. 201301Y0105381261)资助项目.
Progress in the Research of Copper Promoted C—H Functionalizations for the Synthesis of Fused Heterocycles Bearing Bridgehead Nitrogen
Received date: 2015-04-11
Revised date: 2015-06-04
Online published: 2015-06-12
Supported by
Project supported by the Introduction of Innovative R&D Team Program of Guangdong Province (No. 201301Y0105381261).
张英俊 , 聂飚 , 张霁 . 铜促C—H官能团化合成桥头氮稠杂环化合物的研究进展[J]. 有机化学, 2015 , 35(10) : 2067 -2085 . DOI: 10.6023/cjoc201504013
The copper-catalyzed C—H activation, selective functionalization and the development of cyclization strategy for the synthesis of novel fused-heterocyclic (heterocycles with ring-junction nitrogen or bridgehead nitrogen) compounds are discussed. This class of novel bridgehead nitrogen heterocycles includes indolizine, pyrazolopyridine, benzimidazole and other polyheterocyclic compounds. The series including modern amination, oxidative coupling and Csp2—H, Csp—H, Csp3—H and N—H activation catalyzed by Cu(I) or Cu(II) salts makes this green synthesis a superior and practical method providing entry into complex heterocycles. Some reaction mechanisms have also been summarized.
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