芳甲叉双噁唑啉-铜络合物催化三氟甲基丙酮酸酯与吲哚的傅-克烷基化反应研究
收稿日期: 2015-05-07
修回日期: 2015-06-08
网络出版日期: 2015-06-16
基金资助
国家自然科学基金(Nos. J1210064, 21172255)资助项目.
Studies on the Asymmetric Catalytic Friedel-Crafts Alkylation of Indoles with Trifluoromethyl Pyruvate Catalyzed by Heteroarylidene-BOX-Cu Complexes
Received date: 2015-05-07
Revised date: 2015-06-08
Online published: 2015-06-16
Supported by
Project supported by the National Natural Science Foundation of China (Nos. J1210064, 21172255).
殷伯翰 , 吴燕华 , 麻红利 , 马晓东 , 傅滨 , 刘吉平 . 芳甲叉双噁唑啉-铜络合物催化三氟甲基丙酮酸酯与吲哚的傅-克烷基化反应研究[J]. 有机化学, 2015 , 35(10) : 2119 -2124 . DOI: 10.6023/cjoc201505013
This paper reported the reaction of indoles with trifluoromethyl pyruvate catalyzed by heteroaryliden-tethered bis-oxazoline-Cu(II) complex, and the effects of ligand structure, solvent, temperature and different indole substrates on the catalytic reactions were investigated. The results indicate that the reaction furnished high reactivity and moderate to good enantioselectivity, and the substituents on the indole ring have important impact on the reaction. The reaction can afford the indole derivatives with a chiral tertiary carbon center bearing trifluoromethyl substituent in high yields with moderate to good enantioselectivities.
Key words： trifluoromethyl; Friedel-Crafts; indole; bis-oxazoline
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